Diabetes mellitus (DM) is a condition that consists of inefficient insulin management commencing to disorders in carbohydrate, protein, and fatty metabolism. The condition is a segment of the “metabolic syndrome,” a clinical spectrum of irregular lipid and glucose metabolism.

Over recent decades, the incidence of DM has increased worldwide due to a sedentary lifestyle and the rising epidemic of obesity. Lifestyle adjustment is an individual approach operated to review DM and connected complexities; still, incompetent to counter to lifestyle modification is an implication for medical practice.

Regrettably, practice with medical factors may have meaningful side outcomes, and recurring agreements may display required to produce positive clinical outcomes. Hence, the pursuance of distinct medical agents with insignificant side conclusions prevails a sought-after option for the victorious treatment of DM.



In a study performed by Grover et al., rats were fed high-fructose diets to induce hyperglycemia and insulin resistance and then treated with PM orally for thirty days. The authors hypothesized that PM treatment would counteract the metabolic side effects of a high-fructose diet by mitigating hyperglycemia, hyperinsulinemia, and hyperglycemia.

Results of the study show that rats fed high-fructose diets combined with PM treatment had lower levels of hyperinsulinemia, hyperglycemia, and complete prevention of hyperglycemia. It has been hypothesized that the anti glycemic properties possessed by PM are attributed to pterostilbene.

Experiments performed by Manickam and colleagues assessed the anti glycemic effects of pterostilbene isolated from PM in a streptozocin- (STZ-) induced rat model of hyperglycemia and found that oral dosing of 20 mg/kg pterostilbene significantly reduced plasma glucose levels by 42% and body mass by 20%.



The described antioxidant and antihyperglycemic actions of pterostilbene may converse a shielding influence corresponding complexities in inadequately regulated DM patients by limiting hyperglycemia and associated liver and kidney d


The definite correlation among antioxidant motion and glucose regulation produced by pterostilbene practice has not been clarified; nevertheless, it is proposed that pterostilbene improves antioxidant activity commencing to developed glucose metabolism. The increased antioxidant activity produced by pterostilbene may improve tissue resilience against hyperglycemia-generated ROS and prevent end-organ damage.


The human applicability of pterostilbene’s anti-diabetic effects is still unknown. Nemes-Nagy et al. studied the impact of blueberry extract on antioxidant motion in DM children and discovered that practice with blueberry concentrate for two months significantly improved erythrocyte SOD and GPx motion and diminished levels of HbA1c.

Such results may be attributable to the antioxidant activity of pterostilbene; however, additional studies are needed to identify the blueberry-derived mediator and investigate a plausible association with pterostilbene.

Ultimately, the glucose and lipid-lowering effects like Palmitoylethanolamide (PEA) at of the dietary compound pterostilbene may contribute to its clinical potential for the prevention or treatment of diabetes. Additional investigation is imminent to discover pterostilbene’s risk-reducing and therapeutic outcomes in DM people.

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